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Chinese Protein Adulteration

History

Main article: Timeline of the 2007 pet food recalls

The contaminated vegetable proteins were imported from China in 2006 and early 2007 and used as pet food ingredients. The process of identifying and accounting for the source of the contamination and for how the contaminant causes sickness is ongoing.

The first recalls were announced by Menu Foods late on Friday, 16 March 2007 for cat and dog food products in the United States. By 30 March the United States began to ban imports of wheat gluten from China. The Chinese government responded on 4 April by categorically denying any connection to the North American food poisonings refusing to allow inspection of facilities suspected of producing contaminated products.

However, on 6 April 2007, the Chinese government told the Associated Press they would investigate the source of the wheat gluten and by 23 April China gave permission to FDA investigators to enter the country. On 25 April Chinese authorities began to shut down and destroy the implicated factories and detain their managers. The following day, China's Foreign Ministry said it had banned the use of melamine in food products, admitting that products containing melamine had cleared customs while continuing to dispute the role of melamine in causing pet deaths. China also vowed to cooperate with U.S. investigators to find the "real cause" of pet deaths.

The United States Senate held an oversight hearing on the matter by 12 April. The economic impact on the pet food market has been extensive, with Menu Foods losing roughly $30 million alone from the recall.

On 24 April 2007, for the first time FDA officials said that melamine had been detected in feed given to animals raised for human consumption within the United States.

As of 7 May 2007, United States food safety officials stated: "There is very low risk to human health from consuming meat from hogs and chickens known to have been fed animal feed supplemented with pet food scraps that contained melamine and melamine-related compounds"

Investigations

In the 2007 outbreak, as all three pet food ingredients containing melamine had been imported from China, investigators focused their inquiries there. Another concern was been raised by allegations that one contract manufacturer of pet food had included contaminated ingredients from China without the knowledge or approval of the pet food marketers. Melamine had also been purposely added as a binder to fish feed manufactured in the United States from ingredients produced in Ohio. This adulteration has not been linked to any illness. The FDA issued a warning to Tembec, the manufacturer of the adulterated binding ingredients. In response, Tembec declared that, in addition to completing the recall of all products containing the adulterated binding ingredients, it would "discontinue manufacturing and marketing of [the products] as aquatic feed binder. Tembec's aquatic feed binder products were also used by another US company, Uniscope, to produce a binder (XtraBond) for livestock feeds. This binder and the feeds made from it were not recalled, nor was the meat of the livestock fed on these feeds. No fish or fish products were recalled as a result of having been raised on the adulterated feeds.

In 2008, investigation of kidney problems in Chinese infants focused on domestic dairy suppliers in China.

Melamine production and use in China

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Melamine is commonly produced from urea, mainly by either catalyzed gas-phase production or high pressure liquid-phase production, and is soluble in water. Melamine is used combined with formaldehyde to produce melamine resin, a very durable thermosetting plastic, and melamine foam, a polymeric cleaning product. The end products include counter-tops, fabrics, glues and flame retardants. Occasionally, melamine-formaldehyde resin is added to gluten for non-food purposes, such as adhesives or fabric printing.

Melamine is also a byproduct of several pesticides, including cyromazine. The Food Safety and Inspection Service (FSIS) of the United States Department of Agriculture (USDA) provides a test method for analyzing cyromazine and melamine in animal tissues in its Chemistry Laboratory Guidebook which "contains test methods used by FSIS Laboratories to support the Agency's inspection program, ensuring that meat, poultry, and egg products are safe, wholesome and accurately labeled." In 1999, in a proposed rule published in the Federal Register regarding cyromazine residue, the United States Environmental Protection Agency (EPA) proposed "remov[ing] melamine, a metabolite of cyromazine from the tolerance expression since it is no longer considered a residue of concern."

Melamine production in China has also been reported as using coal as raw material. This production has been described as also producing "melamine scrap" which is not "pure melamine but impure melamine scrap that is sold more cheaply as the waste product after melamine is produced by chemical and fertilizer factories here." Shandong Mingshui Great Chemical Group, the company reported by the New York Times as producing melamine from coal, produces and sells both urea and melamine but does not list melamine resin as a product. Melamine production in China has increased greatly in recent years and was described as in "serious surplus" in 2006 . In the United States Geological Survey 2004 Minerals Survey Yearbook, in a report on worldwide nitrogen production, the author stated that "China continued to plan and construct new ammonia and urea plants using coal gasification technology."

The off-gas in production contains large amounts of ammonia (see melamine synthesis). Therefore melamine production is often integrated into urea production which uses ammonia as feedstock. Crystallization and washing of melamine generates a considerable amount of waste water, which is a pollutant if discharged directly into the environment. The waste water may be concentrated into a solid (1.5-5% of the weight) for easier disposal. The solid may contain approximately 70% melamine, 23% oxytriazines (ammeline, ammelide and cyanuric acid), 0.7% polycondensates (melem, melam and melon).

In January 2009, China's Ministry of Industry and Information Technology promulgated draft production permit rules aiming to stem a melamine production glut. Melamine had been widely sold, including over the Internet, for around 10,000 yuan ($1,500) a metric tonne. The ministry also aimed to shrink the number of melamine producers by setting minimum production levels and strengthening controls on ingredients and waste.

Suspicion of contamination in China

Further information: Food safety in the People's Republic of China

Melamine manufacturing and the chemical processes in which melamine are used are completely unrelated to the manufacture or processing of food products such as wheat gluten. On 9 April the FDA stated that there is a "distinct possibility" that the food was intentionally contaminated. According to Senator Richard J. Durbin, one theory that investigators are exploring is whether melamine was added to fraudulently increase the measured protein content, which determines the value of the product. Some analysis methods for determining protein content actually measure the amount of nitrogen present, on the assumption that only protein in the sample contributes significantly to its nitrogen content. Melamine contains a very high proportion of nitrogen. According to Liu Laiting, a Chinese professor of animal sciences, melamine is also hard to detect in ordinary tests.

Glutens

Xuzhou Anying Biologic Technology Development Company (), an agricultural products company based in Xuzhou, Jiangsu, China, which U.S. officials believe was the source of the melamine-contaminated gluten, are maintaining innocence and assert that they are cooperating with officials. The general manager for Xuzhou Anying has denied that his company exported goods and says that they are researching who might have exported their product. They note that per Chinese law, all exported wheat gluten is tested and that they were simply a middle man for local producers. However, a truck driver who has carried goods for Xuzhou Anying contradicted this, saying "they have a factory that makes wheat gluten." Officials in the USDA and FDA believe that Xuzhou Anying labeled its wheat gluten as "nonfood" and exported through a third party, Suzhou Textiles Silk Light & Industrial Products. The nonfood designation would allow the gluten to be shipped without inspection, however a spokesman for Suzhou Textiles has denied that the company exported any wheat gluten.

There is evidence that Xuzhou Anying, despite being a food ingredient supplier, has sought out large quantities of melamine in the past. The New York Times has reported that as recently as 29 March 2007, representatives of Xuzhou Anying wrote, "Our company buys large quantities of melamine scrap" on a message board for the trading of industrial materials. Melamine may have been added to enhance the apparent protein content of the wheat gluten. However, the importer of the wheat gluten, ChemNutra, claims that they received from Xuzhou Anying results of analyses showing "no impurities or contamination." It has not yet been determined whether Xuzhou Anying products other than wheat gluten have been shipped to North America.

The second Chinese supplier involved in shipping melamine-contaminated food ingredients, Binzhou Futian Biology Technology, has been working with importer Wilbur-Ellis since July 2006 . Binzhou Futian supplies soy, corn and other proteins to the United States, Europe and Southeast Asia. Binzhou typically ships rice protein concentrate in white bags but on 11 April one bag was pink and had the word "melamine" stenciled on it. Binzhou explained to Wilbur-Ellis that the original bag had broken and a mislabeled, but new, bag had been used. The company only supplies food and feed ingredients.

Stephen Sundlof, director of the FDA's Center for Veterinary Medicine, said that melamine turning up in exported Chinese wheat gluten, rice protein concentrate and corn gluten supports theories of intentional adulteration. "That will be one of the theories we will pursue when we get into the plants in China."

On 29 April 2007 and 30 April 2007, the International Herald Tribune and New York Times reported that some animal feed manufacturers in China admit to having used melamine scrap in animal feed for years. Said Ji Denghui, general manager of the Fujian Sanming Dinghui Chemical Company: any companies buy melamine scrap to make animal feed, such as fish feed. I don know if there a regulation on it. Probably not. No law or regulation says on do it, so everyone doing it. The laws in China are like that, aren they? If there no accident, there won be any regulation. Such use of "melamine scrap", described as leftover from processing of coal into melamine for use in creating plastic and fertilizer, was described as widespread. Melamine is said to have been chosen in order to inflate crude protein content measures and to avoid tests for other common and illegal ingredients, such as urea.

As of 2 May 2007, officials of the USDA and FDA still do not know who manufactured the contaminated food or where the contamination took place. The Chinese government has said that Xuzhou Anying, for instance, purchased its products from 25 different manufacturers.

On 8 May 2007, The International Herald Tribune reported that three Chinese chemical makers have said that animal feed producers often purchase, or seek to purchase, the chemical, cyanuric acid, from their factories to blend into animal feed to give the false appearance of a higher level of protein, suggesting another potentially dangerous way that melamine and cyanuric acid might combine in protein products.

The same day, FDA officials revealed that the vegetable proteins were not only contaminated, but mislabeled. Both the wheat gluten and rice protein concentrate were actually wheat flour, a much cheaper product from which wheat gluten is extracted. The addition of nitrogen-rich compounds were necessary to make the flour test as if it were protein extract.

Dairy

Further information: 2008 Chinese milk scandal

On 11 September 2008, fresh reports of massive outbreak of melamine contamination found in China led to recall of Baby Formula products in China. Some Chinese reports said the manufacturer of the milk products might not have consciously added Melamine to their milk powder, however they could have used a soy protein substitute to lower production costs, and the source of their soy substitute had melamine added to it. Many Chinese babies had developed kidney stones and other acute kidney problems in recent months across China, investigation led to the discovery of this contaminant. Some people were wondering how much melamine has already entered food products designated for adults without discovery. More worrying are claims reported in China that there are now new chemicals that can be added to food to lower production costs, and yet pass the tests for melamine and other related chemicals. Impact of this incident to dairy industry outside China is beginning to unravel.

By the end of September 2008, the Chinese government said that 22 dairy companies, including Sanlu and export brands like Mengniu and Yili, had produced powdered baby formula that contained traces of melamine. Some dairy farmers interviewed in Hebei Province said it was an open secret that milk was adulterated. Some dairies routinely watered down milk to increase profits, then added other cheap ingredients so the milk could pass a protein test. "Before melamine, the dealers added rice porridge or starch into the milk to artificially boost the protein count, but that method was easily tested as fake, so they switched to melamine, said Zhao Huibin, a dairy farmer near Shijiazhuang.

Investigators say the adulteration was nothing short of a wholesale re-engineering of milk. Researchers established that workers at Sanlu and at a number of milk-collection depots were diluting milk with water; they added melamine to dupe a test for determining crude protein content. "Adulteration used to be simple. What they did was very high-tech," says Chen Junshi, co-chair of the Sino-U.S. workshop and a risk-assessment specialist at China's Center for Disease Control and Prevention. Investigators subsequently learned that the emulsifier used to suspend melamine also boosted apparent milk-fat content. Sanlu baby formula contained a whopping 2563 mg/kg of melamine, adding 1% of apparent crude protein content to the formula, where normal milk is 3.0% to 3.4% protein. Chen says a dean of a school of food science told him that it would take a university team 3 months to develop this kind of concoction. Investigators have concluded that as-yet-unidentified individuals cooked up a protocol for a premix, a solution normally designed to fortify foods with vitamins or other nutrients but, in this case, it was posisonous. Several milk-collecting companies were using the same premix, Chen says: "So someone with technical skill had to be training them."

Non-protein nitrogen as a feed additive

Further information: Non-protein nitrogen

Ruminant animals can obtain protein from at least some forms of non-protein nitrogen (NPN) through fermentation by their rumen bacteria, hence NPN is often added to their diet to supplement protein. Nonruminants such as cats, dogs and pigs (and humans) cannot utilize NPN. NPN are given to ruminants in the form of pelleted urea, ammonium phosphate and/or biuret. Sometimes slightly polymerized special urea-formaldehyde resin or a mixture of urea and formaldehyde (both are also known as formaldehyde-treated urea) is used in place of urea, because the former provides a better control on the nitrogen release. This practice is carried out in China and other countries, such as Finland , India and France.

Cyanuric acid has also been used as NPN. For example, Archer Daniels Midland manufactures an NPN supplement for cattle, which contains biuret, triuret, cyanuric acid and urea. FDA permits a certain amount of cyanuric acid to be present in some additives used in animal feed and also drinking water.

Melamine use as NPN for cattle was described in a 1958 patent. In 1978, however, a study concluded that melamine "may not be an acceptable nonprotein N source for ruminants"ecause its hydrolysis in cattle is slower and less complete than other nitrogen sources such as cottonseed meal and urea.

In China, it is known that ground urea-formaldehyde resin is a common adulterant in feed for non-ruminants. Domestically it is often sold under the euphemism "protein essence" () and is described as "one kind of new proteinnitrogen feed additive". However, urea-formaldehyde resin itself has been suggested as appropriate for use in feed for some non-ruminants in at least one UN FAO report, suggesting its use as a binder in feed pellets in aquaculture.

There is at least one report of inexpensively priced rice protein concentrate (feed grade) containing non-protein nitrogen being marketed for use in non-ruminants dating back to 2005 . In a news item on its website, Jiangyin Hetai Industrial Co., Ltd. warned its customers of low-priced "PSEUDO rice protein" for sale in the market by another unnamed supplier, noting that the contaminant could be detected by analyzing the isoelectric point. It is not clear from that report whether the contaminant in that case was melamine or some other non-protein nitrogen source or whether any contaminated rice protein concentrate made it into the food supply at that time.

On 18 Apr 2007, an ad was posted on the trading website Alibaba.com selling "Esb protein powder" in Xuzhou Anying's name. The product is said to be protein in nature and suitable for livestock and poultry feed, yet claims a crude protein content of 160-300%. It also mentions in passing the product makes use of "NPN" which is an acronym for non-protein nitrogen. Similar ads were placed on other websites, some dated as early as 31 Oct 2005. Products with similar descriptions were also sold as "EM bacterium active protein forage" by Shandong Binzhou Xinpeng Biosciences Company and "HP protein powder" by Shandong Jinan Together Biologic Technology Development Company.

Protein testing

Further information: Protein_in_nutrition#Testing_in_foods

Resonance structures of the peptide bond that links individual amino acids to form a protein polymer.

Proteins, unlike most other food components, contain nitrogen, making nitrogen measurement a common surrogate for protein content. The standard tests for crude protein content used in the food industry (Kjeldahl method and Dumas method are used for official purposes) measure total nitrogen.

Accidental contamination and intentional adulteration of protein meals with non-protein nitrogen sources that inflate crude protein content measurements have been known to occur in the food industry for decades. To ensure food quality, purchasers of protein meals routinely conduct quality control tests designed to detect the most common non-protein nitrogen contaminants, such as urea and ammonium nitrate.

At least one pet food manufacturer not involved in any recalls, The Honest Kitchen, has reacted to the news of melamine contamination by announcing that it would add melamine testing to the suite of quality control tests it already conducted on all ingredients it purchases.

In at least one other segment of the food industry, the dairy industry, some countries (at least the U.S., Australia, France and Hungary), have adopted "true protein" measurement, as opposed to crude protein measurement, as the standard for payment and testing: "True protein is a measure of only the proteins in milk, whereas crude protein is a measure of all sources of nitrogen and includes nonprotein nitrogen, such as urea, which has no food value to humans. ... Current milk-testing equipment measures peptide bonds, a direct measure of true protein." Measuring peptide bonds in grains has also been put into practice in several countries including Canada, the UK, Australia, Russia and Argentina where near-infrared reflectance (NIR) technology, a type of infrared spectroscopy is used. The Food and Agriculture Organization of the United Nations (FAO) recommends that only amino acid analysis be used to determine protein in, inter alia, foods used as the sole source of nourishment, such as infant formula, but also provides: "When data on amino acids analyses are not available, determination of protein based on total N content by Kjeldahl (AOAC, 2000) or similar method ... is considered acceptable."

Allegations of manufacturing and product tampering

The 26 April 2007 and 27 April 2007 recalls by Blue Buffalo, Diamond, Harmony Farms, and Natural Balance are claimed by all 4 brands to be due to unauthorized inclusion of rice protein by American Nutrition, Inc. (ANI), their manufacturer. This adds a new potential source of contamination and distrust, namely non-compliant contract manufacturers, beyond the original problematic Chinese ingredient suppliers. Diamond and Natural Balance refer to this as a "manufacturing deviation" by ANI. Blue Buffalo and Harmony Farms characterize this as "product tampering" by ANI. ANI's recall notice makes no comment on these allegations.

Melamine adulteration and contamination in the U.S.

On 31 May 2007, the International Herald Tribune reported that melamine has also been purposely added as a binder to fish and livestock feed manufactured in the United States and traced to suppliers in Ohio and Colorado.

In autumn 2008, the Food and Drug Administration detected traces of melamine in one top-selling brand of infant formula and traces of cyanuric acid in another brand. Separately, a third major formula maker said that in-house tests had detected trace levels of melamine in its infant formula. The three firms manufacture more than 90 percent of all infant formula produced in the United States. The FDA and other experts said the melamine contamination in U.S.-made formula had occurred unintentionally during the manufacturing process and were not a safety concern.

Impact on human food supply

In early 2007, U.S. officials publicly said that they do not believe melamine alone to be harmful to humans. However, there was too little data at that time to determine how it reacts with other substances, in particular, the combination of melamine with cyanuric acid, a similar chemical known to be found in the waste product of at least some methods of melamine production, and which combination some American and Canadian scientists have suggested may have led to the pet deaths through kidney failure. On 25 May, 2007 in a US FDA/CSFAN Interim Melamine and Analogues Safety/Risk Assessment, FDA stated: "While it is entirely possible that the analogues are more or less potent than the parent compound, melamine, we have no information that assesses the relative potency of the three analogues as compared to melamine; therefore, for the purpose of this interim assessment, we have made an assumption of equal potency. It has been hypothesized that melamine may interact synergistically with its three analogues, but no studies have been conducted that specifically test this hypothesis. Very preliminary work suggests that if it does occur, the formation of lattice crystals, particularly between melamine and cyanuric acid, takes place at very high dose levels and is a threshold and concentration dependent phenomenon that would not be relevant to low levels of exposure. Although still under investigation, it now appears that the combination of melamine and cyanuric acid has been linked to the acute renal failure in cats and dogs that have eaten the suspect pet foods...."

In the United States, five potential vectors of impact on the human food supply have been identified. The first, which has already been acknowledged to have occurred by FDA and U.S. Department of Agriculture officials, is via contaminated ingredients imported for use in pet foods and sold for use as salvage in animal feed which has been fed to some number of hogs and chickens, the meat from which has been processed and sold to some number of consumers: "There is very low risk to human health" in such cases involving pork and poultry. On 1 May 2007, the FDA and USDA stated that millions of chickens fed feed tainted with contaminated pet food had been consumed by an estimated 2.5 to 3 million people.

The second potential vector is via contaminated vegetable proteins imported for intended use as animal feed, which has apparently been acknowledged to occur with regard to fish feed in Canada, while the third possible route is via contaminated vegetable proteins imported for intended use in human food products, and the FDA has issued an import alert subjecting all Chinese vegetable proteins to detention without examination.

A fourth potential vector is referred to in the 10 May 2007 FDA-USDA press conference, viz. incorporation of contaminated vegetable proteins into products intended for human use and subsequent importation.

A fifth vector is acknowledged to have occurred in the 30 May 2007 FDA/USDA press conference, whereby U.S. manufacturers of livestock and shrimp/fish feed have acknowledged adding melamine to their products as a binder.

The original Xuzhou Anying wheat gluten was "human grade," as opposed to "feed grade," meaning that it could have been used to make food for humans such as bread or pasta. At least one contaminated batch was used to make food for humans, but the FDA quarantined it before any was sold. The FDA also notified the Centers For Disease Control and Prevention to watch for new patients admitted to hospitals with renal failure. There have been no observed increases in human illnesses and little human food has tested as contaminated, however the FDA still has not accounted for all of the Xuzhou Anying wheat gluten.

Reports of widespread melamine adulteration in Chinese animal feed have raised the possibility of wider melamine contamination in the human food supply in China and abroad. Despite the widely reported ban on melamine use in vegetable proteins in China, at least some chemical manufacturers continue to report selling it for use in animal feed and in products for human consumption. Said Li Xiuping, a manager at Henan Xinxiang Huaxing Chemical in Henan Province: "Our chemical products are mostly used for additives, not for animal feed. Melamine is mainly used in the chemical industry, but it can also be used in making cakes."

In 2009, The World Health Organization(WHO) published a report on a December 2008 expert meeting held in cojunction with the FAO concluding, inter alia, that "a tolerable daily intake (TDI) of 0.2 mg/kg body weight for melamine was established. The TDI is applicable to the whole population, including infants." However, the experts also noted: "This TDI is applicable to exposure to melamine alone. ... Available data indicate that simultaneous exposure to melamine and cyanuric acid is more toxic than exposures to each compound individually. Data are not adequate to allow the calculation of a health-based guidance value for this co-exposure."

Background

Main article: Timeline of the 2007 pet food recalls#The Human Food Supply

Further information: Timeline of the 2008 Chinese milk scandal

Whole hogs that had eaten contaminated feed were sold to individuals in California

On 3 April 2007, the Boston Globe reported that tainted wheat gluten ended up in factories that produce food for human consumption. Then, on 19 April, Federal U.S. officials said that they were investigating reports that Binzhou Futian rice protein had been used in hog feed, but declined to specify where. The California Department of Food and Agriculture placed American Hog Farm in Ceres, California under quarantine, after melamine was found in the urine of the hogs on the farm. California State Veterinarian Dr. Richard Breitmeyer said "All animals appear healthy," and that "It is unknown if the chemical will be detected in meat." American Hog Farm primarily supplies whole hogs to individuals. Anyone who has purchased a pig from American Hog Farm since 3 April is advised not to eat it. According to California state officials, approximately 45 state residents consumed pork from hogs that had been fed melamine-contaminated feed.

On 24 April 2007, FDA officials said that melamine was in feed given to hogs (and in one case, in Missouri, to chickens) in California, New York, North Carolina, South Carolina, Utah and possibly Ohio. FDA also said that it was adding testing of imported ingredients and finished products that contain cornmeal, corn gluten, rice bran and soy protein to the tests it is already conducting for melamine in wheat gluten and rice protein concentrate ingredients and products.

Dr. David Acheson, assistant FDA commissioner for food protection, announced on 3 May that the FDA had begun to investigate domestic food manufacturers who use protein products to ensure that no contaminated product is being used in foods intended for human use, noting that it has no evidence of this occurring, "but it's prudent to look."

FDA/USDA acknowledge contaminated food supply

On 28 April 2007, the USDA and the FDA, in a joint press release acknowledged that pork from hogs fed contaminated feed had entered the human food supply, stating: "Based on information currently available, FDA and USDA believe the likelihood of illness after eating pork from swine fed the contaminated product would be very low."

On 30 April 2007, the USDA and the FDA updated their 28 April food safety position to include poultry, reflecting contaminated feed being fed to chickens in Indiana.

Risks to human health from this mode of entering the human food supply have been said to be low according to a number of FDA, CDC and university toxicologists, though it was acknowledged that how melamine had harmed cats and dogs "remains something of a mystery".

On 7 May 2007, the USDA and the FDA issued a joint press release reflecting the combined judgment of five federal agencies with regard to the risk to humans in consuming meat from animals fed feed contaminated with tainted pet food scraps, concluding: "There is very low risk to human health" in such cases involving pork and poultry. The risk assessment was conducted by scientists from FDA,the Food Safety and Inspection Service (FSIS) of USDA, Centers for Disease Control and Prevention (CDC), the Environmental Protection Agency (EPA), and U.S. Customs and Border Protection: "In the most extreme risk assessment scenario, when scientists assumed that all the solid food a person consumes in an entire day was contaminated with melamine at the levels observed in animals fed contaminated feed, the potential exposure was about 2,500 times lower than the dose considered safe" using criteria established prior to current research focusing on the apparent increased toxity related to the interaction of melamine and cyanuric acid in vivo for which there is no established safe dosage. FDA and USDA are in the process of identifying a group of experts to convene a scientific advisory board that would be charged with reviewing the risk assessment and contributing to future scientific analysis related to the risk of melamine and its compounds to humans and animals.

On 8 May 2007, some fish intended for human consumption was also announced as having consumed feed contaminated with tainted pet food scraps. According to the Assistant Commissioner for Food Safety of the FDA, "We do not believe that there is any significant risk associated with consuming these fish." Though the FDA declined to identify the states involved in the recall, the Oregon Department of Fish and Wildlife said contaminated fish feed had been found at the Marion Forks Hatchery. They also said that the company that provided the feed, Skretting, had shipped the same lot of feed to six other hatcheries in Oregon.

On 10 May 2007, on further inquiry into the risk to animal and human health of ingesting melamine and cyanuric acid in combination, Dr. David Acheson, Assistant Commissioner for Food Protection with the FDA said: "I'm not aware of any published studies on that. I have seen some preliminary data that would indicate that they are additive. When you put the two together, they are additive rather than synergistic.... The risk assessors also estimated that even if synergism were to occur, it would be unlikely to result in more than a tenfold increase in overall toxicity, and that still gives you a very large margin of safety." No data supporting additivity was produced at this time. No basis for estimating a tenfold increase in risk in the case of synergism was offered.

On 15 May 2007, USDA announced that swine that ate melamine-tainted food have been cleared for human consumption. About 56,000 pigs have been affected in several states. However, no tests have been carried out on the effects of cyanuric acid in pork as well as possible effects of interaction with melamine in the body. While the statement also said that there is no evidence of bioaccumulation of melamine alone, no mention was made whether bioaccumulation might be affected by the interaction of melamine and cyanuric acid in vivo particularly in swine kidneys.

On 3 October, 2008 (updated 28 November 2008), in response to FDA learning that melamine might be contained in infant formula manufactured by a firm in China, FDA updated its 2007 interim risk assessment: "Infants may be more sensitive than adults to exposures because, for example, infant formula is the sole source of nutrition, exposure continues for up to 12 months, and renal function may be more immature compared to adults. This raises a high degree of uncertainty with regard to the determination of safety/risk. ... Therefore, if 100% of the diet were contaminated at a level of 1.26 ppm of melamine, an infant daily intake would equal 0.063 mg/kg bw/d. This value of 1.26 ppm is rounded down to 1.0 ppm melamine to provide an additional margin of safety."

FDA detains Chinese imports without examination

On 27 April 2007, the FDA subjected all vegetable proteins imported from China, intended for human or animal consumption, to detention without physical examination, including: Wheat Gluten, Rice Gluten, Rice Protein, Rice Protein Concentrate, Corn Gluten, Corn Gluten Meal, Corn By-Products, Soy Protein, Soy Gluten, Proteins (includes amino acids and protein hydrosylates), and Mung Bean Protein.

These ingredients are used in such diverse products as breakfast cereal, pizza dough, baby formula, and protein shakes although at the time, there is "no evidence" that any contaminated ingredients have been used to produce human foods, according to Dr. David Acheson, chief medical officer at the FDA's Center for Food Safety and Applied Nutrition.

FDA requests monitoring by Centers for Disease Control

In addition to now testing a wide variety of imported food products and ingredients for melamine contamination, FDA has also "asked the Centers for Disease Control and Prevention to use its surveillance network to monitor for signs of human illness, such as increased renal failure, that could indicate contamination of the human food supply."

On 2 May 2007, Bernadette Burden, a CDC spokeswoman, was reported as saying that a CDC survey of poison control centers, veterans hospitals and a sample of private hospitals had found no increase in reports of kidney diseases.

U.S. federal testing methods

The Food Safety and Inspection Service (FSIS) of the United States Department of Agriculture (USDA) provides a test method for analyzing cyromazine and melamine in animal tissues in its Chemistry Laboratory Guidebook which "contains test methods used by FSIS Laboratories to support the Agency's inspection program, ensuring that meat, poultry, and egg products are safe, wholesome and accurately labeled."

On 24 April 2007, Stephen Sundlof, director of the FDA's Center for Veterinary Medicine, told reporters: "We have found cyanuric acid. It is somewhat related to melamine. Another compound that is very high in nitrogen and we are testing for that compound as well."

On 7 May 2007, the FDA sent a letter to food manufacturers, to remind them "of their legal responsibility to ensure that all ingredients used in their products are safe for human consumption." The FDA has made available to food manufacturers a procedure providing a general guide for the sample preparation and analysis of wheat gluten and pet food matrices for melamine using gas chromatography/mass spectrometry, the same methodology used by the FERN laboratories.

On 15 May 2007, the process for testing meat from swine was validated by USDA's Food Safety and Inspection Service (FSIS).

Human food supply outside of U.S.

Media reports have raised the possibility that melamine may be widely used as an ingredient in human food products in China. According to a report from the Chinese Ministry of Health, 294,000 infants had been affected by melamine-contaminated infant formula by the end of November 2008. More than 50,000 infants have been hospitalized, and six deaths have been confirmed. Because of the large potential health impact, the World Health Organization (WHO) and the Food and Agriculture Organization of the United Nations (FAO) convened an Expert Meeting.

Official EC statements

On 7 June 2007 (updated 4 July 2007), the European Food Safety Authority (EFSA), in EFSA's Provisional Statement on a Request from the European Commission Related to Melamine and Structurally Related Compounds such as Cyanuric acid in Protein-rich Ingredients Used for Food and Feed, concluded: "EFSA provisionally recommends to apply a TDI of 0.5 mg/kg b.w. for the total of melamine and its analogues .... A source of uncertainty is the combined toxicity of melamine and cyanuric acid and their possible synergistic effects in relation to the recently observed toxicity linked to the acute renal failure and death of pet animals (cats and dogs) in the U.S. This mechanism is currently under investigation."

On 21 June 2007, The Health & Consumer Protection Directorate-General of the European Commission (EC) in reporting the Summary Minutes of the Meeting of the Standing Committee on the Food Chain and Animal Health (7 June & acknowledged that corn gluten contaminated with melamine and rice protein concentrate contaminated with melamine and related compounds, both originating firom China, had been intercepted in Poland and Greece, respectively. The minutes further directed that "in case food producing animals have been fed with feed contaminated with melamine and related compounds, there is for the purpose of protecting human health, taking into account the conclusions of the EFSA statement, no need to take restrictive measures as regards the animals which have been fed with contaminated feed and as regards food of animal origin originating from animals fed with contaminated feed."

On 25 September 2008, EFSA issued a press release in response to reports of contaminated milk powder from China which stated, in part: "Children with a mean consumption of biscuits, milk toffee and chocolate made with such milk powder would also not exceed the TDI. However, in worst case scenarios with the highest level of contamination, children with high daily consumption of milk toffee, chocolate or biscuits containing high levels of milk powder would exceed the TDI. Children who consume both such biscuits and chocolate could potentially exceed the TDI by up to more than three times."

Impact on human pharmaceutical supply

In August 2009 the United States Food and Drug Administration advised pharmaceutical manufacturers that they should determine if they are using components possibly contaminated with melamine and test those compenents at risk, as well as make sure they get certifications from suppliers that at-risk components have been tested appropriately. A new guidance lists 27 components the agency considers to be at risk of melamine contamination based on its search of U.S. Pharmacopeia/National Formulary monographs and its Inactive Ingredient Database. The list which includes adenine, ammonium salts, gelatin, guar gum, lactose, povidone and taurine is not all-inclusive, the guidance says. "For the purpose of this guidance, we use the term at-risk component to mean those ingredients or raw materials that rely on a test for nitrogen content for their identity or purity or strength, and that contain nitrogen in amounts greater than 2.5 percent."

Reaction

In China

Further information: 2008 Chinese milk scandal

Chinese government

The contaminated wheat gluten came from a company located in the Jiangsu Province in eastern China.

Once wheat gluten had been isolated as the source of the problems, federal investigators in the United States began to trace the gluten used in the foods. All of the gluten came from ChemNutra's Kansas City warehouse. ChemNutra said it imported nearly 800 metric tons of wheat gluten from the Xuzhou Anying Biologic Technology Development Company of Xuzhou, Jiangsu, China between 29 November and 8 March. ChemNutra says the gluten came directly from China or from China through the Netherlands, and that it received no reports of contamination in the chemical analysis provided by Xuzhou Anying Biologic Technology Development Company. The products were shipped from the company's Kansas City warehouse to several pet food makers and one distributor of pet food ingredients in the US and Canada, including the companies affected by the recall. Xuzhou Anying also exports carrots, garlic, ginger, corn protein powder, vegetables and feed.

On 5 April 2007, several days after the United States halted all wheat gluten imports, the Chinese government categorically denied any connection to the North American food poisonings to the New York Times, claiming they had no record of exporting any agricultural products that could have tainted the recalled pet foods, including the wheat gluten that has been the focus of the investigation. The general manager of the Xuzhou Anying Biologic Technology Development Company also denied that they had exported any wheat gluten to North America.

However, on 6 April 2007, the Chinese government told the Associated Press they would investigate the source of the wheat gluten. Although the government refused to give details on the investigation, the Xinhua News Agency stated that "sampling and examination" of wheat gluten was under way across China, centering on the presence of melamine. Officials with office of the General Administration of Quality Supervision, Inspection and Quarantine, said that they will stay in touch with the U.S. Embassy in Beijing and that "further measures would be taken based on developments in the United States."

Starting on 4 April 2007, the Chinese government refused US FDA requests to inspect facilities suspected of producing contaminated products. On 11 April, the director of the FDA's field investigations division said he was disappointed with the Chinese response. On 23 April, after refusing for nearly a month, China finally gave permission to FDA investigators to enter the country.

On 25 April 2007, Chinese authorities shut down Binzhou Futian Biology Technology Co. Ltd., and detained the manager, Tian Feng. Feng has denied responsibility, saying that he "didn't do anything wrong," and denying that he even knew what melamine was. The following day, China's Foreign Ministry said it has banned the use of melamine in food products, admitting that products containing melamine had cleared customs while continuing to dispute the role of melamine in causing pet deaths. China also vowed to cooperate with U.S. investigators to find the "real cause" of pet deaths. China provided a transcript of the 26 April press conference indicating that an invitation to FDA investigators had been sent on 23 April, but making no mention of banning melamine usage.

On 3 May 2007, Chinese authorities detained Mao Lijun, general manager of the Xuzhou Anying Biologic Technology Development, one of the companies accused of exporting contaminated protein, on unspecified charges, perhaps showing that the Chinese government is taking additional steps in its own investigations and signaling cooperation with US FDA investigators who arrived in China on Monday.

On 9 May 2007, Chinese authorities took a number of steps to address food safety concerns.

On 29 May 2007, in actions not linked directly to the protein export scandal, Xinhua reported that Zheng Xiaoyu (), the former head of China's ministry of food and drug safety, had been convicted of personally approving unproven and unsafe medicines after taking bribes from eight pharmaceutical companies totaling more than 6.49 million RMB, (or a rough equivalent of 850,000 US dollars), which resulted in at least hundreds patient deaths, or perhaps even thousands, and as a result, he was sentenced to death. It was also discovered during his eight year reign as the head of China's ministry of food and drug safety, Zheng Xiaoyu had personally ordered to approval of more than 150,000 new medicines, an average of astonishing 134 times that of FDA, which only approves 140 or so new medicines annually. Not surprisingly, most of those 150,000 medicines were the products of the eight pharmaceutical companies that bribed Zheng Xiaoyu, and a single unsafe medication of Anhui Hua Yuan () Company (since closed with its CEO committed suicide before his arrest) resulted 14 patient deaths and hundreds being permanently disabled. Zheng Xiaoyu's former deputy was also convicted, for accepting more than two million RMB (or a rough equivalent of a quarter million US dollars) to help Zheng Xiaoyu. The former deputy was sentenced to a two year delayed death sentence and a new system for unsafe food recall would be implemented by the end of the year. However, the general public sentiment in China was that this was only the tip of the iceberg, because in the case of Zheng Xiaoyu, the exact amount of bribe is much higher than what has been revealed so far, and this is confirmed by Zheng Xiaoyu's own confession: in March 2007, Zheng Xiaoyu admitted that the exact amount might never be known for sure because the 6.49 million was only what he accepted, and his wife and son also accepted separate huge amount of bribe which he was not part of, and the investigation on Zheng Xiaoyu's family is still on-going. The Chinese public also believes that as the investigation deepens, the number of confirmed patients who died and were disabled would certainly increase.

In August 2007, Xinhua reported on a number of steps China had recently taken to ensure food safety and product quality, including instituting new product recall and customer notification systems.

In 2008, a number of steps were taken in China in response to the 2008 Chinese milk scandal. A September 25, 2008 article from Xinhua is provided here as a link into some of the "Lessons Learned": "Sanlu, the center of the scandal, provided a bad example of crisis management. When it was first exposed, Sanlu refused to take the blame and passed the buck to innocent dairy farmers, which ignited great anger nationwide. A further official investigation showed Sanlu had lied about its contaminated baby formula for months while thousands of infants got sick and at least three died. Sanlu didn't openly admit its products were toxic until Sept. 11. It eventually recalled baby formula manufactured on and before Aug. 6."

In the United States

Federal government

All of the food recalls executed by companies in the United States and Canada were voluntary, i.e. not mandated by any government agency. In the United States, prior to the recall, the Food and Drug Administration did not keep pet foods under the same level of protection and safety ensurance as food intended for human consumption. According to the FDA, the FDA's "regulation of pet food is similar to that for other animal feeds. The Federal Food, Drug, and Cosmetic Act (FFDCA) requires that pet foods, like human foods, be pure and wholesome, safe to eat, produced under sanitary conditions, contain no harmful substances, and be truthfully labeled." However, "there is no requirement that pet food products have premarket approval by FDA."

Once the recall was announced, the Food and Drug Administration immediately began to mobilize resources to assist in the investigation. The FDA has dedicated each of its 20 district offices and three field laboratories to the investigation and more than "400 employees are involved in sample pet food collection, monitoring of recall effectiveness, and preparing consumer complaint reports." The FDA has activated its Emergency Operations Center, making sure the information on the poisoning gets to scientists and inspection teams. The agency "is also working with its regulatory partners in all 50 state agriculture and health agencies to inform them of the status of the investigative and analytical efforts." The FDA issued an alert to its field personnel that they should block import of wheat gluten from Xuzhou Anying Biologic Technology Development Company Ltd., and subject wheat gluten from China and the Netherlands to increased scrutiny.

As a result of the contamination, consumers and pets' rights groups have called for the FDA to take a more active role in ensuring pet food safety. On 2 April 2007, People for the Ethical Treatment of Animals called for the resignation of the FDA commissioner, Dr. Andrew von Eschenbach.

Possibly in response to growing concern about ensuring the safety of the U.S. food supply, on 1 May 2007, Dr. von Eschenbach announced the creation of an Assistant Commissioner for Food Protection to advise on "strategic and substantive food safety and food defense matters." Dr. David Acheson will fill this roll. According to Dr. von Eschenbach, "The protection of America's food supply and therefore the safety of Americans eating food of domestic or international origin is of utmost importance to me as a physician, and to the mission of this agency."

U.S. Congress

In the aftermath of the recall, there was a call from consumers for an investigation into Menu Foods reaction to the poisonings, and the federal government's stand on pet food safety and quality control and the FDA's response to the recall. On 1 April 2007, Senator Dick Durbin (D - Illinois) called on the FDA to "account for weak links in the pet food inspection system." Earlier in the week, Representative Rosa DeLauro (D - Connecticut) asked for an analysis of the FDA's oversight of pet food manufacturing facilities and a report of actions taken since the recall.

On 6 April 2007, Senator Durbin criticized the federal inspection process for both human and pet food and called for the hearings on the matter. According to the Los Angeles Times who interviewed Durbin 8 April, Durbin said he would like to see the FDA set national standards and inspection rules for pet food manufacturing facilities, and to see "federal law changed to allow the FDA to order a recall of food intended for human or pet consumption rather than rely on companies to do it voluntarily."

Durbin is working with Senator Herb Kohl (D - Wisconsin), the Chairman of the United States Senate Appropriations Subcommittee on Agriculture, Rural Development, Food and Drug Administration, and Related Agencies. Senator Kohl initiated hearings in the Senate Appropriations Subcommittee along with Senator Durbin and Senator Bob Bennett (R - Utah). Senator Robert Byrd (D - West Virginia), from the United States Senate Committee on Appropriations was there as well. Witnesses included FDA officials. They looked into several areas: the delay in reporting by Menu Foods, the lack of federal inspections of pet food facilities, and incomplete reporting by the FDA since the start of the recall.

During the hearing Senators Durbin and Byrd criticized the government's response during the recall. Durbin specifically criticized the lack of any regular inspection practices or quality control with regards to pet food safety. Senator Kohl criticized the FDA's communication to the public about recalled foods, noting that volunteer websites had more detailed and easier-to-access information about the extent of the problem and which specific foods are of concern than FDA's online resources which Kohl said was contradictory of itself at times, and which the FDA official giving testimony admitted to being difficult to navigate.

On 18 April 2007, Senator Durbin and Representative DeLauro met with US FDA Commssioner von Eschenbach to discuss the additional rice protein recalls and learned that the Chinese government was blocking outside attempts to investigate the contamination. In response, they sent a letter to Zhou Wenzong, China's Ambassador to the United States saying in part that "contaminated batches of wheat gluten and rice protein responsible for these events were imported from China" and that "no level of melamine should be found in pet or human food" and asking for visas for inspectors from the United States.

Public

The protein export scandal inspired a significant amount of US media attention to Chinese food safety concerns, and increased unease about Chinese imports amongst the American public. A July 2007 Consumer Reports poll found that 92 percent of Americans favored "country of origin" labeling on meat products, while in a USA Today/Gallup poll, 74 percent of US respondents said they were "somewhat concerned" or "very concerned" about the safety of food imported from China.

See also

2007 pet food recalls

2007 Chinese export recalls

2008 Chinese milk scandal

International Reaction to the 2008 Dairy Scandal

Food safety in the People's Republic of China

References

^ a b Katie Burns and Susan Kahler (15 June 2007). "Ongoing recall investigation unraveling the facts". Journal of the American Veterinary Medical Association. http://www.avma.org/onlnews/javma/jun07/070615m.asp. Retrieved 2007-06-08. 

^ a b c Barboza, David (8 May 2007). "Second chemical eyed in Chinese pet food scandal". New York Times. http://iht.com/articles/2007/05/08/business/petfood.php. Retrieved 2007-05-08. 

^ a b c d Roebuck, Karen (11 April 2007). "Chinese criticized in pet food probe". Pittsburgh Tribune-Review. http://pittsburghlive.com/x/pittsburghtrib/news/rss/s_502101.html. Retrieved 2007-04-11. 

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^ a b c "IMPORT ALERT #99-29, "DETENTION WITHOUT PHYSICAL EXAMINATION OF ALL VEGETABLE PROTEIN PRODUCTS FROM CHINA FOR ANIMAL OR HUMAN FOOD USE DUE TO THE PRESENCE OF MELAMINE AND/OR MELAMINE ANALOGS"". U.S. Food and Drug Administration. 27 April 2007. http://web.archive.org/web/20071012074202/www.fda.gov/ora/fiars/ora_import_ia9929.html. Retrieved 2007-05-01. 

^ a b "Feds: Millions have eaten chickens fed tainted pet food". CNN. 2 May 2007. http://www.cnn.com/2007/HEALTH/05/02/pet.food.poultry/index.html. Retrieved 2007-05-02. 

^ a b c d Andrew Martin (31 May 2007). "Poison used in China is found in U.S.-made animal feed". The New York Times. http://www.iht.com/articles/2007/05/31/business/food.1-65273.php. Retrieved 2007-06-01. 

^ Telegraph

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^ a b AP (26 April 2007). "China Bans Melamine in Food Products". New York Times. http://www.nytimes.com/aponline/world/AP-China-Pet-Food-Recall.html. Retrieved 2007-04-26. 

^ a b Delgado, Benna (9 April 2007). "UPDATE: Pet Food Recall Controversy Headed to U. S. Senate". CaribJournal.com. http://caribjournal.com/2007/04/09/update-pet-food-recall-controversy-headed-to-u-s-senate/. Retrieved 2007-04-11. 

^ a b Abruzzese, Sarah (25 April 2007). "F.D.A. Says Livestock Were Fed Pet Food With Suspect Chemical". New York Times. http://www.nytimes.com/2007/04/25/us/25petfood.html. Retrieved 2007-04-25. 

^ a b c d "FDA/USDA Joint News Release: Scientists Conclude Very Low Risk to Humans from Food Containing Melamine". U.S. Department of Agriculture and U.S. Food and Drug Administration. 7 May 2007. http://web.archive.org/web/20071220001153/www.fda.gov/bbs/topics/NEWS/2007/NEW01629.html. Retrieved 2007-05-07. 

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^ Schmit, Julie (17 April 2007). "Premium pet food company recalls dry foods". USA Today. http://www.usatoday.com/money/industries/2007-04-17-premium-pet-food-recalled_N.htm. Retrieved 2007-04-17. 

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^ a b Swaminathan, Nikhil (25 April 2007). "Were Our Pets Deliberately Poisoned?". Scientific American. http://www.sciam.com/article.cfm?articleID=2B10D1F6-E7F2-99DF-34DAAAC1622FE3CE&chanID=sa007. Retrieved 2007-04-26. 

^ a b "Natural Balance Pet Foods, Inc. Recalls Products in Response to American Nutrition Inc. Pet Food Recall". http://www.naturalbalanceinc.com/press_release4_27_07.html. Retrieved 2007-04-28. 

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^ a b "Blue Buffalo Recalls Can and Biscuit Products Due To Tampering By American Nutrition Inc.". http://www.bluebuff.com/company/news_070426.shtml. Retrieved 2007-04-26. 

^ a b "Harmony Farms Cans And Biscuits Recalled Due To Product Tampering". http://harmonypetproducts.com/index...
About the Author

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Briefe an Erich von Kahler (1940-1951) $98 Die Briefe vermitteln ein Bild von Brochs politischen Diskussionen mit Kahler (Zweiter Weltkrieg, die Erfindung der Atombombe, das Nachkriegsdeutschland, die Gründung Israels, die Rolle des Intellektuellen). Darin werden u.a. die Intentionen seiner Romane und seiner Massenwahntheorie sowie der kulturhistorischen Schrift „Hofmannsthal und seine Zeit" thematisiert. Im Persönlichen werden altösterreichische Retrospektiven eingeschaltet, aktuelle Frauenfreundschaften geschildert und die Bemühungen seiner Gönner kommentiert, seinen Ruhm zu befördern.

Babel by Kahler, Hugh Macnair [Hardcover] $52.51 This is a pre1923 historical reproduction that was curated for quality. Quality assurance was conducted on each of these books in an attempt to remove books with imperfections introduced by the digitization process. Though we have made best efforts the books may have occasional errors that do not impede the reading experience. We believe this work is culturally important and have elected to bring the book back into print as part of our continuing commitment to the preservation of printed works worldwide. Author: Kahler, Hugh Macnair Binding Type: Hardcover Number of Pages: 376 Publication Date: 2008/12/09 Language: English Dimensions: 6.14 x 9.21 x 0.88 inches

Die Brucke Der Iris (1905) by Kahler, Erich [Hardcover] $39.48 Author: Kahler, Erich Binding Type: Hardcover Publication Date: 2010/09/10 Language: German Dimensions: 9.00 x 6.00 x 0.44 inches

Locally Conformal Kahler Geometry $285.17 Author: Dragomir, Sorin/ Dragmoir, Sorin/ Ornea, Liuiu Series Title: Progress in Mathematics Series Number: 155 Binding Type: Hardcover Number of Pages: 348 Publication Date: 1997/12/18 Language: English Dimensions: 6.14 x 9.21 x 0.81 inches

Infinite Dimensional Kahler Manifolds $58.45 No Synopsis Available

Canonical Metrics in Kahler Geometry $48.7 No Synopsis Available

Lectures on Kahler Manifolds $42.9 No Synopsis Available

LOCALLY CONFORMAL KAHLER GEOMETRY $109.6 No Synopsis Available

Bob Kahler by Toll, Aaron Philippe [Paperback] $78.07 Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Robert William Kahler (born February 13, 1917) is a former American football player and coach. He played defensive back and halfback in the National Football League for the Green Bay Packers from 1942 to 1944. Kahler played college football at the University of NebraskaLincoln and professionally in the NFL for three seasons. He retired from playing in 1944. After military service in World War II, Kahler returned to Nebraska as an assistant football and track coach. In 194748, he was the head football and track coach at Nebraska City High School. In 1948, he moved to State Normal School and Teachers College in Wayne, Nebraska, now Wayne State College, as head football coach and led his team to a share of the Nebraska College Conference championship. The following year, he moved to Northern Illinois University, where he served as head coach for one season in 1955. Author: Toll, Aaron Philippe Binding Type: Paperback Number of Pages: 100 Publication Date: 2011/05/19 Language: English Dimensions: 9.02 x 5.98 x 0.24 inches

Die Brucke Der Iris (1905) by Kahler, Erich [Paperback] $25.7 Author: Kahler, Erich Binding Type: Paperback Number of Pages: 112 Publication Date: 2010/09/10 Language: German Dimensions: 6.00 x 9.02 x 0.23 inches

B.C. Rich Kerry King Wartribe Electric Guitar With Kahler Tremolo Black With Red $499.99 B.C. Rich Kerry King Wartribe Electric Guitar with Kahler Tremolo Black With Red

Chinese Hotch Potch by Kahler, William R. [Hardcover] $46.66 This is a pre1923 historical reproduction that was curated for quality. Quality assurance was conducted on each of these books in an attempt to remove books with imperfections introduced by the digitization process. Though we have made best efforts the books may have occasional errors that do not impede the reading experience. We believe this work is culturally important and have elected to bring the book back into print as part of our continuing commitment to the preservation of printed works worldwide. Author: Kahler, William R. Binding Type: Hardcover Number of Pages: 282 Publication Date: 2009/06/04 Language: English Dimensions: 9.21 x 6.14 x 0.69 inches

Kahler Inn and Suites - Mayo Clinic Area $145 Kahler Inn and Suites Mayo Clinic Area is located in central Rochester, close to Mayo Clinic, University of Minnesota Rochester, and Mayo Civic Center. Nearby points of interest also include Rochester Civic Theater and Rochester Art Center. Hotel Features. Dining options at Kahler Inn and Suites Mayo Clinic Area include a restaurant and a coffee shop/caf?. The hotel serves a complimentary continental breakfast. Recreational amenities include an indoor pool, a spa tub, and a fitness facility. The property offers a roundtrip airport shuttle (surcharge). Self parking is complimentary. Additional property amenities include an arcade/game room, gift shops/newsstands, and laundry facilities. This is a smoke free property. A total renovation of this property was completed in June 2011. Guestrooms. 271 air conditioned guestrooms at Kahler Inn and Suites Mayo Clinic Area feature coffee/tea makers and electronic check out. Beds come with triple sheeting. Wireless Internet access is complimentary. Guestrooms offer phones with voice mail. Flat panel televisions have cable channels. Also included are complimentary toiletries and clock radios. Housekeeping is offered daily and guests may request wake up calls. Guestrooms are all non smoking. Notifications and Fees:The following fees and deposits are charged by the property at time of service, check in, or check out. Pet fee: USD 100 per stayEarly check in fee: USD 50Late check out fee: USD 99Rollaway bed fee: USD 10 per night The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change. Notifications and Fees:The following fees and deposits are charged by the property at time of service, check in, or check out. Pet fee: USD 100 per stayEarly check in fee: USD 50Late check out fee: USD 99Rollaway bed fee: USD 10 per night The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.